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There are over 3000 studies on Carnosine in the National Library Of Medicine. We have compiled the to Clinical Studies, Reviews an Publication and divided them into Catagories. To get started just click the catagory you would like more info on below
BRAIN HEALTH & NEUROLOGICAL
Human Studies:
Study: “Brain type carnosinase in dementia: a pilot study” (2007).
Summary: Reduced brain carnosinase activity was observed in dementia patients, suggesting a role for carnosine metabolism in cognitive disorders.
Study: “Carnosine supplementation in elderly subjects: A randomized, double-blind, placebo-controlled trial” (2016).
Summary: Carnosine supplementation improved cognitive function and physical performance in elderly subjects, indicating broad health benefits.
Animal Studies:
Study: “L-homocarnosine, L-carnosine, and anserine attenuate brain oxidative damage in a pentylenetetrazole-induced epilepsy model of ovariectomized rats” (2018).
Summary: Carnosine, L-homocarnosine, and anserine reduced oxidative brain damage in ovariectomized rats with induced epilepsy, suggesting neuroprotective effects.
Study: “Carnosine is neuroprotective against permanent focal cerebral ischemia in mice” (2007).
Summary: Carnosine protected mice against permanent focal cerebral ischemia, indicating potential as a neuroprotective agent in stroke models.
Study: “β-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer’s disease” (2013).
Summary: Carnosine supplementation improved cognitive function in Alzheimer’s model mice fed a high-fat diet, suggesting a role in mitigating neurodegenerative decline.
Study: “Carnosine and its possible roles in nutrition and health” (2009).
Summary: Carnosine showed neuroprotective effects in animal models of brain injury, supporting its potential in neurological health.
Reviews:
Study: “Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders” (2022).
Summary: Carnosine modulates brain cell activity through multiple mechanisms, showing therapeutic potential for neurodegenerative disorders like Alzheimer’s and Parkinson’s.
Study: “Carnosine in health and disease” (2018).
Summary: Carnosine exhibits neuroprotective effects in brain tissues, with potential applications in treating neurological disorders due to its antioxidant and anti-inflammatory properties.
Study: “Carnosine and the processes of ageing” (2016).
Summary: Carnosine’s antioxidant properties may protect against age-related neurological decline, supporting its use in brain health.
ANTI-AGING
In-Vitro Studies:
Study: “Carnosine prevents necrotic and apoptotic death of rat thymocytes via mitochondrial pathway” (2009).
Summary: Carnosine prevented cell death in rat thymocytes in vitro, suggesting anti-aging effects by protecting against mitochondrial dysfunction.
Reviews:
Study: “Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper” (2022).
Summary: Carnosine’s anti-aging effects stem from its ability to detoxify reactive oxygen species and prevent protein cross-linking, supporting its use in age-related conditions.
Study: “Physiology and pathophysiology of carnosine” (2013).
Summary: Carnosine’s antioxidant and anti-glycation properties make it a promising agent for combating age-related cellular damage and senescence.
Study: “Carnosine and the processes of ageing” (2016).
Summary: Carnosine’s anti-glycation and antioxidant effects may slow aging processes, particularly in cellular senescence (duplicate from Brain Health, included for partial fit).
BLOOD SUGAR / DIABETES
Human Studies:
Study: “A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus” (2010).
Summary: A carnosinase gene polymorphism was associated with increased mortality and progression to end-stage renal disease in type 1 diabetes patients, indicating a genetic link to carnosine metabolism.
Study: “Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial” (2016).
Summary: Carnosine supplementation improved insulin sensitivity in humans, suggesting potential benefits for glucose metabolism in diabetes management.
Animal Studies:
Study: “Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice” (2014).
Summary: Carnosine supplementation reduced plasma triglycerides and altered plaque composition in diabetic mice, suggesting cardiovascular benefits in diabetes.
Study: “Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats” (2008).
Summary: Carnosine eye drops prevented cataract formation in diabetic rats, highlighting its protective effects against diabetic complications.
Study: “Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress” (2010).
Summary: Carnosine reduced oxidative stress in diabetic rat brains exposed to ethanol, suggesting protective effects against diabetic neurological complications.
Reviews:
Study: “Effects of supplementation with carnosine and other histidine-containing dipeptides on chronic disease risk factors and outcomes: protocol for…” (2018).
Summary: The protocol outlines research to evaluate carnosine’s potential in reducing chronic disease risk factors, particularly in diabetes and related complications.
Study: “Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation” (2021).
Summary: Carnosine shows promise as a functional food ingredient for managing diabetic nephropathy and other chronic conditions due to its antioxidant properties.
PHYSICAL PERFORMANCE
Human Studies:
Study: “Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance” (2010).
Summary: Beta-alanine supplementation increased muscle carnosine levels, enhancing exercise performance in humans.
Study: “Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters” (2007).
Summary: Beta-alanine supplementation increased muscle carnosine and reduced fatigue in sprinters, improving performance during intense exercise.
Animal Studies:
Study: “Effect of beta-alanine and carnosine supplementation on muscle contractility in mice” (2013).
Summary: Carnosine and beta-alanine supplementation improved muscle contractility in mice, supporting their role in enhancing muscle function.
Reviews:
Study: “Carnosine: from exercise performance to health” (2013).
Summary: Carnosine enhances exercise performance by buffering muscle pH and has broader health benefits due to its antioxidant effects.
Study: “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation” (2019).
Summary: Beta-alanine supplementation, which increases carnosine levels, is safe and effective for improving exercise performance, with minimal side effects.
Study: “Role Niehs-Bolton effect of carnosine and anserine on exercise performance and quality of life in older adults: A systematic review and meta-analysis” (2020).
Summary: Carnosine supplementation improved physical performance and quality of life in older adults, supporting its ergogenic benefits.
EYE HEALTH
Animal Studies:
Study: “Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats” (2008).
Summary: Carnosine eye drops reduced cataract formation in diabetic rats, suggesting a protective role against ocular diabetic complications.
Reviews:
Study: “Physiology and pathophysiology of carnosine” (2013).
Summary: Carnosine’s antioxidant properties may offer therapeutic potential for ocular diseases, including cataracts.
SKIN HEALTH
Reviews:
Study: “Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper” (2022).
Summary: Carnosine’s antioxidant effects may support skin health by protecting against UV damage and aiding wound healing.
CANCER
In-Vitro Studies:
Study: “Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling” (2019).
Summary: Carnosine inhibited glioblastoma cell growth in vitro, independent of the PI3K/Akt/mTOR pathway, suggesting a novel anti-cancer mechanism.
Study: “Carnosine retards reactive oxygen species-mediated hamster cheek pouch carcinogenesis” (2010).
Summary: Carnosine reduced reactive oxygen species-mediated carcinogenesis in hamster cheek pouch cells in vitro, indicating anti-cancer potential.
Study: “Carnosine inhibits migration and invasion of colorectal cancer cells by disrupting the STAT3 signaling pathway” (2021).
Summary: Carnosine inhibited migration and invasion of colorectal cancer cells in vitro by disrupting STAT3 signaling, suggesting anti-metastatic effects.
Reviews:
Study: “Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper” (2022).
Summary: Carnosine inhibits cancer cell proliferation and may enhance chemotherapy efficacy, offering potential as an anti-cancer agent.
Study: “Carnosine in health and disease” (2018).
Summary: Carnosine’s anti-proliferative effects on cancer cells suggest therapeutic potential in oncology, particularly for glioblastoma.
MISCELLANEOUS
Animal Studies:
Study: “The hepatoprotective effect of carnosine against ischemia/reperfusion liver injury in rats” (2007).
Summary: Carnosine protected rat livers from ischemia/reperfusion injury, indicating hepatoprotective effects.
Study: “Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure” (2009).
Summary: Carnosine-like peptides were distributed in the zebrafish nervous system, with chronic exposure affecting embryonic development.
Study: “Carnosine protects against cisplatin-induced acute kidney injury in mice” (2015).
Summary: Carnosine reduced cisplatin-induced kidney damage in mice, suggesting renoprotective effects.
Reviews:
Study: “Carnosine: its properties, functions and potential therapeutic applications” (1992).
Summary: Carnosine’s antioxidant and chelating properties suggest broad therapeutic applications across various health conditions.
Study: “Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation” (2021).
Summary: Carnosine’s multifaceted benefits, including cardiovascular protection, support its use as a functional food ingredient.
Study: “Carnosine and its possible roles in nutrition and health” (2009).
Summary: Carnosine’s antioxidant properties support its potential in cardiovascular and immune health (duplicate from Brain Health, included for partial fit).
In-Vitro Studies:
Study: “Carnosine-induced neuroprotection involves mitochondrial preservation and H2O2 detoxification” (2006).
Summary: Carnosine protected neuronal cells in vitro by preserving mitochondrial function and detoxifying hydrogen peroxide, suggesting broad cellular protective effects.
Study: “Carnosine and homocarnosine interaction with membrane phospholipids” (2009).
Summary: Carnosine and homocarnosine interacted with membrane phospholipids in vitro, indicating a role in stabilizing cellular membranes.
Study: “Carnosine as an inhibitor of protein carbonylation in vitro” (2008).
Summary: Carnosine inhibited protein carbonylation in vitro, suggesting a role in protecting proteins from oxidative damage.
Reviews:
Study: “Carnosine: physiological properties and therapeutic potential” (2000).
Summary: Carnosine’s physiological roles, including pH buffering and metal chelation, suggest diverse therapeutic applications beyond specific diseases.
Study: “Carnosine and anserine as modulators of neutrophil function” (2018).
Summary: Carnosine and anserine modulated neutrophil function, indicating potential in immune system regulation.
Study: “Carnosine metabolism in health and disease” (2023).
Summary: Carnosine metabolism influences various physiological processes, with potential therapeutic roles in multiple health contexts.
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